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7 Therefore, the diet of pregnant mothers, especially during early developmental stages, influences epigenetic changes in the fetus, such as DNA methylation, thereby affecting the expression of developmentally regulated genes. 2 In addition, long-lasting epigenetic changes are evident in the offspring of women who experience famine during the first trimester of pregnancy, but are absent in those who either do not experience famine or who experience it at a later gestational period. 5, 6 The DOHaD theory has been found to apply to many syndromes and disorders, including schizophrenia. 3, 4 Thus, the adverse conditions during gestation may have lasting effects on subsequent health or result in adult-onset diseases due to fetal programming, which is commonly referred to as the Developmental Origin of Health and Disease (DOHaD). 1 For example, epidemiological evidence indicates that exposure to famine in early gestation approximately doubles the risk of schizophrenia in offspring, as observed after the Dutch Hunger Winter (1944–1945) 2 and the Great Chinese Famine (1959–1961). These results suggest that PUFA deficiency during the early neurodevelopmental period in mice could model the prodromal state of schizophrenia through changes in the epigenetic regulation of nuclear receptor genes.Īmong the well-established risk factors for schizophrenia that affect early neurodevelopment, nutritional deficiencies are known to have significant effects. Notably, the expression of these nuclear receptor genes were also downregulated in hair-follicle cells from schizophrenia patients. In addition, the RXR agonist bexarotene upregulated oligodendrocyte- and GABA-related gene expression and suppressed the sensitivity of mice to the hallucinogenic drug. Regulation of these genes was mediated by the nuclear receptor genes Rxr and Ppar, whose promoters were hyper-methylated by the deprivation of dietary AA and DHA.
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Furthermore, a working-memory task-evoked hyper-neuronal activity in the medial prefrontal cortex was also observed, along with the downregulation of genes in the prefrontal cortex involved in oligodendrocyte integrity and the gamma-aminobutyric acid (GABA)-ergic system. In the PUFA-deprived mouse group, we observed lower motivation and higher sensitivity to a hallucinogenic drug resembling the prodromal symptoms in schizophrenia. Here, we show that gestational and early postnatal dietary deprivation of two PUFAs-arachidonic acid (AA) and docosahexaenoic acid (DHA)-elicited schizophrenia-like phenotypes in mouse offspring at adulthood. Polyunsaturated fatty acids (PUFAs) are dietary components that are crucial for the structural and functional integrity of neural cells, and PUFA deficiency has been shown to be a risk factor for schizophrenia. The Model 1076 is specially made for the FBI and does not have a safety catch on the slide, but instead, a frame-mounted de-cocking lever.The risk of schizophrenia is increased in offspring whose mothers experience malnutrition during pregnancy.
#Smith and wesson 915 schematics series
The Model 1000 Series resembles the 5900 Series but is chambered for the 10 mm Auto cartridge. 45 ACP cartridge and adds the power of a well-proven cartridge to the other advantages of the Third Generation system. 40 mm Smith & Wesson with 11 rounds magazine capacity (Photo: S&W) Smith & Wesson 4500 Series 40 Smith & Wesson cartridge and has a magazine capacity of 11 rounds. The Model 4006 generally resembles the Model 5906 but is chambered for the. It is larger and uses the same length of the barrel but has a 12-round magazine Smith & Wesson Model 6906 chambered in 9 mm (Photo: S&W) Smith & Wesson Model 4006 The 9 mm 6900 Series has a reverse-curved trigger-guard. The 9 mm 3900 Series generally resembles the 5900 series but is slimmer, lighter, and with a smaller magazine capacity. Smith & Wesson Model 5903 (Photo: S&W) Smith & Wesson 3900 Series All are fitted with wrap-around grips, adjustable sights are optional, and all have the same 4-inch barrel. There are three models: the 5903, 5904, and 5906 the Smith & Wesson 5903 has an alloy frame and stainless steel slide, the Smith & Wesson 5904 an aluminum frame, carbon steel slide, and stainless steel barrel and is finished in blue, and the Smith & Wesson 5906 is entire of stainless steel and is satin-finished. The 9 mm 5900 Series can be considered as the baseline series. 2 Technical specifications: Smith & Wesson Model 5903 Variants Smith & Wesson 5900 Series